When the familiar suddenly feels unfamiliar, it could be nothing — or something worth noting

Jamais vu is the unsettling sensation that something familiar suddenly feels completely new or strange. French for “never seen,” it’s perhaps best described as the opposite of déjà vu.

While it’s less common, jamais vu is just as fascinating and complex as its more famous counterpart.

What is jamais vu?

“Jamais vu is a false sense of unfamiliarity,” explains neurologist Jean Khoury, MD. “You’re in a setting you know, but your brain fails to recognize it.”

These moments usually pass quickly, but they can leave you feeling disoriented.

It’s worth noting that jamais vu may sound a little like memory loss. After all, when things you should know don’t register anymore, it can be a troubling sign of conditions like dementia or Alzheimer’s disease. But it’s not the same.

“Jamais vu is a feeling of not recognizing something. It’s not that you’ve lost the ability to recognize your surroundings,” Dr. Khoury clarifies. “It’s that there’s a brief pause where you feel out of sorts in your environment.”

Jamais vu examples

Jamais vu can happen in any number of situations, like:

  • You walk into your home and the furniture, lighting and flooring somehow feel eerily new.
  • You’re typing or reading a common word, like “door,” and suddenly it looks wrong — like it’s misspelled or in a foreign language.
  • You’re having a conversation with a friend when their face is momentarily unrecognizable.
  • You’re in your local grocery store, where you’ve shopped for years, when you become disoriented for a moment.
  • You pull a favorite sweatshirt out of your closet and don’t recognize it as your own.

What causes jamais vu?

Jamais vu happens when there’s a brief miscommunication between two areas of your brain — your temporal lobes and hippocampus — that are responsible for recognition and memory. It’s the same process that gives rise to déjà vu.

“Jamais vu happens when there’s a disconnect between your senses and your memory. It’s like your brain is playing tricks on you,” Dr. Khoury explains.

Jamais vu happens when there’s a misfire between your temporal lobes (which help you recognize familiar people and places) and your hippocampus (which takes in new information). Your brain can confuse something that’s old for something that’s new for a brief, fleeting moment.

“Both déjà vu and jamais vu are the result of this same missed connection between the temporal lobe and hippocampus. But how you experience that miscommunication is different,” he continues.

Instead of that unsettling feeling that you’ve seen or experienced something before, you feel like you’ve never seen it — despite knowing that you have.

Health conditions and jamais vu

Jamais vu can be harmless — nothing more than a random glitch in your brain matrix. Or it can be a sign that something else is going on.

Potential triggers include:

  • Mental fatigue: When you’re exhausted, your brain’s ability to process and recognize things can falter.
  • Sleep deprivation: Lack of sleep can impair memory function, making it harder to recognize familiar environments and situations.
  • Stress or anxiety: Extreme stress can disrupt how your brain interprets what’s happening around you. “It can be a protective mechanism,” Dr. Khoury says. “The brain detaches slightly from reality as a coping strategy.”
  • Migraines: People prone to migraines may experience jamais vu during the onset (aura) phase or as a symptom of the migraine episode itself.
  • Temporal lobe epilepsy: Jamais vu can happen in people who experience seizures in their temporal lobe. It can happen at the beginning of a seizure before progressing into other seizure symptoms — or it can be the only sign of a seizure episode.

When to talk to a doctor about jamais vu

Experiencing a few moments of jamais vu once or twice a year? Probably nothing to worry about.

But if you notice it happening more regularly — or lasting longer — it’s worth mentioning to a healthcare provider.

“Episodes that happen more frequently or that last longer than a few seconds can be a red flag,” Dr. Khoury states.

That’s especially true if jamais vu episodes come with other worrying symptoms, like:

  • Memory loss or confusion
  • Intense headaches
  • Loss of awareness or responsiveness
  • Seizures

If you’re unsure whether your experience is typical, trust your intuition: “If it’s enough to make you think about talking to a healthcare provider, that’s probably a sign that it’s worth bringing up,” Dr. Khoury emphasizes.